- Nominated for Outstanding Lead Actress in a Comedy Series at Emmy Awards for The Nanny. (1997)
- Nominated for Best Performance by an Actress in a TV-Series - Comedy/Musical at Golden Globe Awards for The Nanny. (1997)
- Nominated for Outstanding Lead Actress in a Comedy Series at Emmy Awards for The Nanny. (1996)
- Nominated for Best Performance by an Actress in a TV-Series - Comedy/Musical at Golden Globe Awards for The Nanny. (1996)
- Nickname: Frannie
- Trade mark: Flashy outfits and Nasal voice
- Is left-handed.
- Is of Italian and Russian-Jewish Descent.
- Chosen by People (USA) magazine as one of the 50 most beautiful people in the world. (1996)
- Was married to her high school sweetheart Peter Marc Jacobson. They produced 'The Nanny' together.
- Sold her Spanish house to Alfred Gough and now lives in Malibu.
- Appeared on the first cover of Rosie O'Donnell's magazine, Rosie.
- She has a cameo in PICKING UP THE PIECES, a 2000 movie starring Woody Allen and David Schwimmer.
- Her beloved Pomeranian Chester appeared on an episode of The Nanny and was credited as Chester Drescher. Her new chocolate Pomeranian is named Esther Drescher.
- She was admitted to Los Angeles's Cedars Sinai Hospital on 21 June 2000, after doctors diagnosed her with uterine cancer. But emergency surgery caught it early as it was only at Stage 1 and she didn't have to have radiation or chemotherapy. She has been given a clean bill of health and no post-operative treatment has been ordered.
- Went to Hillcrest High School in Queens, New York, as did her former husband, Peter Marc Jacobson.
- Her father, Mort Drescher, has appeared on The nanny (1993) on more than one occasion.
- Is a survivor of uterine cancer.
- Measurements: 34B-24-34 1/2 (Source: Celebrity Sleuth magazine)
- A Patient Advocate on the External Advisory Board for the M.D. Anderson Cancer Centre in Houston, Texas. Also the 2002 recipient of the Public Service Award from the Gynecologic Cancer Foundation.
- Became good friends with Dan Aykroyd and Donna Dixon, after co-starring with them in the 1983 film, DOCTOR DETROIT (1983).
- Abides by a dairy-free diet.
- Was told that she'd never make it in this business unless she lost her thick New York accent.
- Famously bumped into the (then) president of CBS, Jeff Sagansky, on a plane trip to Paris. She convinced him to hear her and her husband Peter's ideas for a television show. After impressing him with her persistence, intelligence, and charm, The Nanny (1993) pilot was filmed less than a year later.
- Was first runner up for Miss New York Teenager in 1973. In order to get an agent, she lied when calling up talent agencies and said she was the winner. It worked and an agent was found.
- Earlier in her career, in an effort to get more roles as an actress, she once went to a professional to lose her nasal voice and thick New York accent. She was very successful in learning how to speak normal, but couldn't get any work that way! By that point, people only wanted to hire if she used the funny voice. Meanwhile, it was the voice that made her famous years later.
- Casting agents continued to tell Fran that her thick Queens accent was holding her back during auditions.
- Fran and Peter moved from New York to Los Angeles in the early eighties.
- In 1985, Fran and Peter's home was broken into. Fran was raped. They moved in with their good friends Dan Aykroyd and Donna Dixon for a short time.
- 'The Nanny' was inspired from a personal experience. Fran visited her friend Twiggy in Europe and while she was there, she stayed with Twiggy's teenage daughter as she traveled quite a bit with her modeling career.
- Her Pomeranian dog Chester died on Christmas, 2000.
Quotes- "Think peace."
- "Inside this body is a chubby girl from Queens. That doesn't go away."
- "Upon constantly being asked if her voice is real: "Who would make this up?"
- "I read for the part of Elizabeth, the virgin queen. I thought they said they were looking for a virgin from Queens. Whatever, the only virgin in my house is the olive oil."
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